Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study.

نویسندگان

  • Bassem Yamout
  • Roula Hourani
  • Haytham Salti
  • Wissam Barada
  • Taghrid El-Hajj
  • Aghiad Al-Kutoubi
  • Aline Herlopian
  • Elizabeth Kfoury Baz
  • Rami Mahfouz
  • Rima Khalil-Hamdan
  • Nabeela M A Kreidieh
  • Marwan El-Sabban
  • Ali Bazarbachi
چکیده

We explore the safety, and therapeutic benefit of intrathecal injection of ex-vivo expanded autologous bone marrow derived mesenchymal stem cells (BM-MSCs) in 10 patients with advanced multiple sclerosis (MS). Patients were assessed at 3, 6 and 12 months. Assessment at 3-6 months revealed Expanded Disability Scale Score (EDSS) improvement in 5/7, stabilization in 1/7, and worsening in 1/7 patients. MRI at 3 months revealed new or enlarging lesions in 5/7 and Gadolinium (Gd+) enhancing lesions in 3/7 patients. Vision and low contrast sensitivity testing at 3 months showed improvement in 5/6 and worsening in 1/6 patients. Early results show hints of clinical but not radiological efficacy and evidence of safety with no serious adverse events.

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عنوان ژورنال:
  • Journal of neuroimmunology

دوره 227 1-2  شماره 

صفحات  -

تاریخ انتشار 2010